Food Grade D-(+)-Trehalose Dihydrate Trehalose Powder High Water Retention , Antioxidant

Food Grade D-(+)-Trehalose Dihydrate Trehalose Powder High Water Retention , Antioxidant

Quick Detail :

Trehalose is a naturally occurred disaccharide and was first discovered in a bacterium grown on rye by Wigglers in 1932. The research followed indicated that trehalose exists widely in natural, mostly in plants and microbes. It is a non-reducing sugar consisting of tow glucose molecules linked by ,α-1,1-glycosidic bond and is one of the most stable sugar in the world. 

  During the research of dehydration of plant cells, scientists found that trehalose can effectively prevent cell membrane, protein and other molecules from damage upon drying, and keep the natural biological character after rehydration of the dried plants. Some insects that can keep alive even under the conditions of hyperthermia, deep-coldness, dehydrating, etc, is largely attributed to the existence of trehalose as the main compoments. It has been proved from the abundant experimental results that trehalose can form a special protective layer around the protein and other biomolecules, efficiently protecting biologicals under harsh conditions such as hyperthermia, deep-coldness, hypertonia, dehydrating, and keep intact their biological characteristics..

Description :

Molecular formula:C12H22O11·2H2O

English Name: D-(+)-Trehalose dehydrate

CAS NO. : 6138-23-4

MDL NO.: MFCD00071594

Molecular weight :378.3                                   

Description: white powder crystal, solubility in water: 68.9g/100g (20), soluble in hot ethanol, insoluble in ether

Physical parameters: melting point: 97-99 degree C (lit.)

Refractive index: 181 degrees (C=7, H2O)

Applications :

Medical Industry

1. Trehalose has been successfully applied to blood products such as vaccine, lymphocyte and other cytokines to stabilize their activities. Trehalose can not only be conserved at an ambient temperature, but also prevent some vital disease such as hepatitis B and AIDS caused by contaminated blood resource from transforming. 

2. Quadrant Research Fund Association, England, found that vaccines and other temperature-vulnerable biologicals which usually require cold storage at 4  is stable at 45 after mixture with trehalose. Thus, the cost of storage and transportation will be greatly decreased while maintaining high potential of vaccine undergoing a far distance transportation.

3. In California, America, John Calau and his collegues has successfully applied trehalose to preserve blood platelet by dehydrating cells and hyophilization, and the platelet can be preserved for a long time at an ambient temperature and showed survival percentage of 85%.

4. Trehalose can be used to keep biological agents such as enzyme, cell membrane, organelle, antibody and virus, and make life-science research more convenient, rapid and effective. Research on the protective function of trehalose on restriction enzyme, DNA ligase and DNA polymerase has been carried out, and results showed that all enzyme samples with addition of trehalose, kept 35 days at 70 or 9 months at 37, maintained nearly 100% of their original activities. The Chinese scientists tested three diagnostic enzymes which were prepared with trehalose as disccant to assay human serum cholesterol, and found that trehalose could keep 90% of their activity after long-term storage at an ambient temperature.

5. Using trehalose as lyophilization protectant can efficiently retain activity of vaccine for domestic animals and poultry and virus-vaccine for man, for example, attenuated hepatitis A virus vaccine, epidemic encephalitis B vaccine. And the inoculated efficiency of vaccine can be kept without low temperature storage and freezing transportation.

Food Industry

1. Protein materials

  Using
Food Grade D-(+)-Trehalose Dihydrate Trehalose Powder High Water Retention , Antioxidant